ABSTRACT
Objective: To study pharmacokinetics of lidocaine during superior laryngeal nerve block (SLNB) combined with topical anesthesia to endotracheal mucosa by thyrocricocentesis(TCC). Method: Eight patients (ASA Ⅰ-Ⅱ grade)scheduled for general anesthesia and operation were performed bilateral SLNB with 2% lidocaine 2mg/kg and TCC with 5 % lidocaine 2mg/kg within 1 min,The internal jugular venous blood samples were taken at 1,5,10,20,30, 60,120 and 180 minutes after lidocaine administrations to determine lidocaine serum concentrations using a fluoresence polarization immunoassy. Pharmacokinetics were calculated with a procedure (3p87) by computer. Result: The pharmacokinetics could be described as two-compartment model. Absorption rates of lidocaine were fast,values of t_(1/2) Ka and Tpeak were 5.0?2.5 min and 7.5?2.1 min respectively。Maximal concentrations (Cmax) of lidocaine were 3.8?0. 6?g/ml, which were within safety ranges. Conclusion: It may be safe that 2% lidccaine 2mg/kg superior laryngeal nerve block is combined with 5% lidocaine 2mg/kg topical anesthesia to endotracheal mucosa by thyrocricocentesis.
ABSTRACT
To observe the effects of urapidil on the cardiovascular responses to tracheal intubation, forty-six patients (ASA Ⅰ - Ⅱ) were randomly divided into group A (n=23) and group B(n=23). Anesthesia was induced with valium 0.2mg/kg, 2.5% thiopental sodium 5mg/kg and tracheal intubation was facilitated with succinylcholine 1.5mg/kg. Urapidil 0.5mg/kg was intravenously given immediately after administration of succinylcholine in group A. After intubation. SP, DP,MAP,HR and RPP increased by 6%,12%, 15%, 24% and 28% in group A and increased by 30%,37%,33%,48% and 95% in group B respectively. Compared correspondingly with those in group B, the values of the parameters mentioned above decreased significantly in 5 minutes after intuhation in group A(P